Drug interactions
Lisdexamfetamine + Omeprazole
Severity: Minor
Lisdexamfetamine and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression can change the absorption timing of amphetamine released from lisdexamfetamine, with an earlier peak concentration. Total exposure is not meaningfully changed, so clinical impact is expected to be small.
What this interaction means in plain words
Lisdexamfetamine and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH modestly alters the rate of absorption of amphetamine without changing overall exposure.
What to do
No dose change is normally needed. Monitor the clinical response to lisdexamfetamine if a PPI is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Omeprazole?
MediHelp rates the interaction as minor. Lisdexamfetamine and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression can change the absorption timing of amphetamine released from lisdexamfetamine, with an earlier peak concentration. Total exposure is not meaningfully changed, so clinical impact is expected to be small.
How serious is the interaction between Lisdexamfetamine and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Monitor the clinical response to lisdexamfetamine if a PPI is started or stopped.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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