Drug interactions
Lisdexamfetamine + Perphenazine
Severity: Moderate
Lisdexamfetamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines block dopamine receptors and can blunt the effects of amphetamines, while stimulants may exacerbate psychosis. Perphenazine can prolong the QT interval, and amphetamines may add to arrhythmic risk in predisposed patients. Sedation effects are opposing.
What this interaction means in plain words
Lisdexamfetamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Opposing dopaminergic effects, with possible additive cardiac effects (QT prolongation plus sympathomimetic stimulation).
What to do
Monitor for psychotic symptoms and consider an ECG in patients with cardiac risk factors or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Lisdexamfetamine with Perphenazine?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines block dopamine receptors and can blunt the effects of amphetamines, while stimulants may exacerbate psychosis. Perphenazine can prolong the QT interval, and amphetamines may add to arrhythmic risk in predisposed patients. Sedation effects are opposing.
How serious is the interaction between Lisdexamfetamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for psychotic symptoms and consider an ECG in patients with cardiac risk factors or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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