Drug interactions
Lisdexamfetamine + Temazepam
Severity: Minor
Lisdexamfetamine and Temazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a sedative-hypnotic benzodiazepine while lisdexamfetamine is a stimulant, so the two have opposing effects on alertness and sleep. Stimulant use late in the day can undermine temazepam's hypnotic effect, and perceived alertness may hide residual impairment.
What this interaction means in plain words
Lisdexamfetamine and Temazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Opposing CNS effects (GABA-A potentiation versus catecholamine release); no significant pharmacokinetic interaction.
What to do
Give lisdexamfetamine in the morning and counsel the patient about residual impairment. Reassess the need for the hypnotic if insomnia stems from the stimulant.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisdexamfetamine and Temazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Lisdexamfetamine with Temazepam?
MediHelp rates the interaction as minor. Lisdexamfetamine and Temazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temazepam is a sedative-hypnotic benzodiazepine while lisdexamfetamine is a stimulant, so the two have opposing effects on alertness and sleep. Stimulant use late in the day can undermine temazepam's hypnotic effect, and perceived alertness may hide residual impairment.
How serious is the interaction between Lisdexamfetamine and Temazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give lisdexamfetamine in the morning and counsel the patient about residual impairment. Reassess the need for the hypnotic if insomnia stems from the stimulant.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
