Drug interactions
Lomitapide + Progesterone
Severity: Moderate
Lomitapide and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising risk of liver enzyme elevation and gastrointestinal effects. The effect is probably modest.
What this interaction means in plain words
Lomitapide and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Progesterone belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by progesterone reduces lomitapide clearance.
What to do
Monitor liver enzymes and GI tolerability, and keep lomitapide dose within labeled limits for patients taking CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Progesterone?
MediHelp rates the interaction as moderate. Lomitapide and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Progesterone is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising risk of liver enzyme elevation and gastrointestinal effects. The effect is probably modest.
How serious is the interaction between Lomitapide and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and GI tolerability, and keep lomitapide dose within labeled limits for patients taking CYP3A4 inhibitors.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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