Drug interactions
Lomustine + Sarilumab
Severity: Moderate
Lomustine and Sarilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine suppresses the bone marrow and immune function, and sarilumab blocks IL-6 receptor signaling, which also impairs defenses and can lower neutrophil counts. The combination may increase the risk of serious infection.
What this interaction means in plain words
Lomustine and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomustine belongs to Oncology; Sarilumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression and neutropenia from cytotoxic therapy plus IL-6 receptor blockade.
What to do
Monitor neutrophil and platelet counts and watch for signs of infection. Interrupt sarilumab if a serious infection or severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Sarilumab
Frequently asked questions
Can I take Lomustine with Sarilumab?
MediHelp rates the interaction as moderate. Lomustine and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine suppresses the bone marrow and immune function, and sarilumab blocks IL-6 receptor signaling, which also impairs defenses and can lower neutrophil counts. The combination may increase the risk of serious infection.
How serious is the interaction between Lomustine and Sarilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil and platelet counts and watch for signs of infection. Interrupt sarilumab if a serious infection or severe neutropenia occurs.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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