Drug interactions
Lonafarnib + Progesterone
Severity: Moderate
Lonafarnib and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may raise progesterone exposure. Progesterone as a weak CYP3A inhibitor may in turn modestly raise lonafarnib levels, which carries arrhythmia risk.
What this interaction means in plain words
Lonafarnib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Progesterone belongs to Endocrine.
Why it happens
Reciprocal CYP3A4 inhibition and competition for metabolism.
What to do
Monitor ECG and for syncope or palpitations, and reduce the lonafarnib dose per labeling if needed. Watch for progestogenic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Progesterone?
MediHelp rates the interaction as moderate. Lonafarnib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may raise progesterone exposure. Progesterone as a weak CYP3A inhibitor may in turn modestly raise lonafarnib levels, which carries arrhythmia risk.
How serious is the interaction between Lonafarnib and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for syncope or palpitations, and reduce the lonafarnib dose per labeling if needed. Watch for progestogenic adverse effects.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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