Drug interactions
Lonafarnib + Ticlopidine
Severity: Moderate
Lonafarnib and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and strong CYP3A inhibitor. Ticlopidine is a CYP3A-relevant drug that can influence lonafarnib exposure. Coadministration could increase lonafarnib adverse effects such as gastrointestinal toxicity, and ticlopidine exposure may also change.
What this interaction means in plain words
Lonafarnib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Ticlopidine belongs to Cardiovascular.
Why it happens
Lonafarnib inhibits CYP3A4, and ticlopidine may affect CYP-mediated clearance of lonafarnib, with mutual effects on exposure.
What to do
Avoid the combination where possible and use an alternative antiplatelet. If needed, monitor for lonafarnib toxicity and for ticlopidine hematologic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Ticlopidine?
MediHelp rates the interaction as moderate. Lonafarnib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate and strong CYP3A inhibitor. Ticlopidine is a CYP3A-relevant drug that can influence lonafarnib exposure. Coadministration could increase lonafarnib adverse effects such as gastrointestinal toxicity, and ticlopidine exposure may also change.
How serious is the interaction between Lonafarnib and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antiplatelet. If needed, monitor for lonafarnib toxicity and for ticlopidine hematologic effects.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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