Drug interactions
Loperamide + Tepotinib
Severity: Moderate
Loperamide and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may raise exposure to loperamide, a P-gp substrate. Increased loperamide exposure can enhance central opioid effects and cardiac effects including QT prolongation.
What this interaction means in plain words
Loperamide and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Tepotinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by tepotinib increases loperamide absorption and CNS penetration.
What to do
Use the lowest effective loperamide dose and avoid exceeding labeled limits. Monitor for sedation, constipation and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Loperamide with Tepotinib?
MediHelp rates the interaction as moderate. Loperamide and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may raise exposure to loperamide, a P-gp substrate. Increased loperamide exposure can enhance central opioid effects and cardiac effects including QT prolongation.
How serious is the interaction between Loperamide and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective loperamide dose and avoid exceeding labeled limits. Monitor for sedation, constipation and palpitations.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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