Drug interactions
Loperamide + Tucatinib
Severity: Moderate
Loperamide and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and CYP3A4 and may increase loperamide exposure. Loperamide is commonly used for tucatinib-related diarrhea, so higher exposure could add to constipation and, at high doses, cardiac or CNS toxicity.
What this interaction means in plain words
Loperamide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Tucatinib belongs to Oncology.
Why it happens
Inhibition of P-gp efflux and CYP3A4 metabolism increases loperamide levels.
What to do
Use loperamide at labeled doses for tucatinib diarrhea and do not exceed the daily maximum; monitor for constipation, sedation and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Loperamide with Tucatinib?
MediHelp rates the interaction as moderate. Loperamide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein and CYP3A4 and may increase loperamide exposure. Loperamide is commonly used for tucatinib-related diarrhea, so higher exposure could add to constipation and, at high doses, cardiac or CNS toxicity.
How serious is the interaction between Loperamide and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use loperamide at labeled doses for tucatinib diarrhea and do not exceed the daily maximum; monitor for constipation, sedation and palpitations.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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