Drug interactions
Lopinavir + Miglitol
Severity: Moderate
Lopinavir and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as lopinavir/ritonavir can cause insulin resistance and hyperglycemia, which may counteract the glucose-lowering effect of miglitol. Glycemic control may deteriorate in diabetic patients after starting therapy.
What this interaction means in plain words
Lopinavir and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Miglitol belongs to Endocrine.
Why it happens
Protease inhibitor-induced insulin resistance opposes the antihyperglycemic effect (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c after starting or changing the antiretroviral regimen. Intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Miglitol?
MediHelp rates the interaction as moderate. Lopinavir and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as lopinavir/ritonavir can cause insulin resistance and hyperglycemia, which may counteract the glucose-lowering effect of miglitol. Glycemic control may deteriorate in diabetic patients after starting therapy.
How serious is the interaction between Lopinavir and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the antiretroviral regimen. Intensify antidiabetic therapy if control worsens.
What other medicines interact with Miglitol?
MediHelp also lists interactions of Miglitol with, for example, Pramlintide, Aripiprazole, Asenapine. The full list is on the Miglitol page.
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