Drug interactions
Lopinavir + Mometasone
Severity: Moderate
Lopinavir and Mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is given with ritonavir, which strongly inhibits CYP3A4 and can raise systemic mometasone levels. This increases the risk of Cushing's syndrome and adrenal suppression.
What this interaction means in plain words
Lopinavir and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Mometasone belongs to Respiratory.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4 metabolism of mometasone.
What to do
Monitor for corticosteroid excess and adrenal suppression. Consider beclomethasone for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Mometasone?
MediHelp rates the interaction as moderate. Lopinavir and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir is given with ritonavir, which strongly inhibits CYP3A4 and can raise systemic mometasone levels. This increases the risk of Cushing's syndrome and adrenal suppression.
How serious is the interaction between Lopinavir and Mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and adrenal suppression. Consider beclomethasone for long-term therapy.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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