Drug interactions
Lopinavir + Nevirapine
Severity: Moderate
Lopinavir and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine lowers lopinavir concentrations, which may reduce antiviral efficacy, particularly in treatment-experienced patients. The coformulated lopinavir/ritonavir is commonly used with nevirapine with a dose adjustment.
What this interaction means in plain words
Lopinavir and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing lopinavir clearance.
What to do
Increase the lopinavir/ritonavir dose as per labeling when given with nevirapine, especially in treatment-experienced patients. Monitor HIV RNA and lopinavir response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Nevirapine?
MediHelp rates the interaction as moderate. Lopinavir and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine lowers lopinavir concentrations, which may reduce antiviral efficacy, particularly in treatment-experienced patients. The coformulated lopinavir/ritonavir is commonly used with nevirapine with a dose adjustment.
How serious is the interaction between Lopinavir and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase the lopinavir/ritonavir dose as per labeling when given with nevirapine, especially in treatment-experienced patients. Monitor HIV RNA and lopinavir response.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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