Drug interactions
Lopinavir + Ondansetron
Severity: Moderate
Lopinavir and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir inhibits CYP3A4 and may raise ondansetron exposure, and lopinavir/ritonavir can also prolong the QT interval. Together they may increase the risk of QT prolongation.
What this interaction means in plain words
Lopinavir and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 inhibition by ritonavir-boosted lopinavir plus additive QT effects.
What to do
Use the lowest effective ondansetron dose and monitor the ECG in patients with cardiac risk factors. Correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Ondansetron?
MediHelp rates the interaction as moderate. Lopinavir and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir inhibits CYP3A4 and may raise ondansetron exposure, and lopinavir/ritonavir can also prolong the QT interval. Together they may increase the risk of QT prolongation.
How serious is the interaction between Lopinavir and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ondansetron dose and monitor the ECG in patients with cardiac risk factors. Correct potassium and magnesium.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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