Drug interactions
Lopinavir + Ranolazine
Severity: Contraindicated
Lopinavir and Ranolazine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is given with ritonavir, a strong CYP3A4 inhibitor, which raises ranolazine levels and the risk of QT prolongation and toxicity.
What this interaction means in plain words
Lopinavir and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lopinavir belongs to Anti Virals; Ranolazine belongs to Cardiovascular.
Why it happens
Ritonavir-boosted CYP3A4 inhibition reduces ranolazine clearance.
What to do
Do not co-administer. Use an alternative antianginal during lopinavir/ritonavir therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Ranolazine?
MediHelp rates the interaction as contraindicated. Lopinavir and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir is given with ritonavir, a strong CYP3A4 inhibitor, which raises ranolazine levels and the risk of QT prolongation and toxicity.
How serious is the interaction between Lopinavir and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative antianginal during lopinavir/ritonavir therapy.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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