Drug interactions
Lopinavir + Sevoflurane
Severity: Major
Lopinavir and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong the QT and PR intervals, and sevoflurane can also lengthen the QT interval. The combination may increase the risk of arrhythmia during anesthesia. Ritonavir also affects the metabolism of some co-administered anesthetic drugs.
What this interaction means in plain words
Lopinavir and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lopinavir belongs to Anti Virals; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Check a baseline ECG and electrolytes and monitor the ECG throughout the procedure. Review other perioperative drugs for CYP3A4 interactions with ritonavir.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Sevoflurane?
MediHelp rates the interaction as major. Lopinavir and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir/ritonavir can prolong the QT and PR intervals, and sevoflurane can also lengthen the QT interval. The combination may increase the risk of arrhythmia during anesthesia. Ritonavir also affects the metabolism of some co-administered anesthetic drugs.
How serious is the interaction between Lopinavir and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the ECG throughout the procedure. Review other perioperative drugs for CYP3A4 interactions with ritonavir.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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