Drug interactions
Lopinavir + Tiotropium-olodaterol
Severity: Moderate
Lopinavir and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong QT and PR intervals, and olodaterol may add arrhythmic risk via hypokalemia and tachycardia. Ritonavir may also raise olodaterol exposure through CYP3A and P-gp inhibition.
What this interaction means in plain words
Lopinavir and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with possible increased olodaterol exposure via CYP3A inhibition.
What to do
Obtain an ECG and correct electrolytes in patients with QT risk factors. Monitor for tachycardia, palpitations and tremor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Lopinavir and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can prolong QT and PR intervals, and olodaterol may add arrhythmic risk via hypokalemia and tachycardia. Ritonavir may also raise olodaterol exposure through CYP3A and P-gp inhibition.
How serious is the interaction between Lopinavir and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct electrolytes in patients with QT risk factors. Monitor for tachycardia, palpitations and tremor.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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