Drug interactions
Lopinavir + Trazodone
Severity: Moderate
Lopinavir and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir inhibits CYP3A4 and can raise trazodone concentrations, with greater sedation, hypotension, and arrhythmia risk. Both drugs also have some QT-prolonging potential.
What this interaction means in plain words
Lopinavir and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Trazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated trazodone metabolism, plus possible additive QT prolongation.
What to do
Start trazodone at a low dose and titrate slowly, using the lowest effective dose. Monitor sedation, blood pressure, and ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Trazodone?
MediHelp rates the interaction as moderate. Lopinavir and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir inhibits CYP3A4 and can raise trazodone concentrations, with greater sedation, hypotension, and arrhythmia risk. Both drugs also have some QT-prolonging potential.
How serious is the interaction between Lopinavir and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start trazodone at a low dose and titrate slowly, using the lowest effective dose. Monitor sedation, blood pressure, and ECG in patients with cardiac risk factors.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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