Drug interactions
Lopinavir + Vortioxetine
Severity: Moderate
Lopinavir and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is given with ritonavir, which inhibits CYP2D6 and CYP3A4 and could raise vortioxetine levels. Increased exposure may cause more nausea and other adverse effects, although ritonavir may also induce some enzymes, making the net effect uncertain.
What this interaction means in plain words
Lopinavir and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Vortioxetine belongs to Central Nervous System.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP2D6 and CYP3A4, decreasing vortioxetine clearance.
What to do
Monitor tolerability and consider a lower vortioxetine dose, such as half the usual dose, if adverse effects occur. Re-titrate after the antiretroviral is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Vortioxetine?
MediHelp rates the interaction as moderate. Lopinavir and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir is given with ritonavir, which inhibits CYP2D6 and CYP3A4 and could raise vortioxetine levels. Increased exposure may cause more nausea and other adverse effects, although ritonavir may also induce some enzymes, making the net effect uncertain.
How serious is the interaction between Lopinavir and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tolerability and consider a lower vortioxetine dose, such as half the usual dose, if adverse effects occur. Re-titrate after the antiretroviral is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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