Drug interactions
Lopinavir + Zileuton
Severity: Moderate
Lopinavir and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which can increase exposure to zileuton, a CYP3A4 substrate. Higher zileuton levels may increase the risk of hepatotoxicity and other adverse effects.
What this interaction means in plain words
Lopinavir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Zileuton belongs to Respiratory.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4, slowing zileuton metabolism.
What to do
Monitor liver enzymes regularly and for symptoms of hepatic injury. Reduce or stop zileuton if ALT rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Zileuton?
MediHelp rates the interaction as moderate. Lopinavir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which can increase exposure to zileuton, a CYP3A4 substrate. Higher zileuton levels may increase the risk of hepatotoxicity and other adverse effects.
How serious is the interaction between Lopinavir and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes regularly and for symptoms of hepatic injury. Reduce or stop zileuton if ALT rises.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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