Drug interactions
Loratadine + Pregabalin
Severity: Minor
Loratadine and Pregabalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes somnolence and dizziness and carries a warning for respiratory depression with other CNS depressants. Loratadine is minimally sedating, so additive effects are likely small but may matter in vulnerable patients.
What this interaction means in plain words
Loratadine and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Pregabalin belongs to Central Nervous System.
Why it happens
Possible additive CNS depression through pharmacodynamic synergism.
What to do
No routine change is needed; counsel about drowsiness and driving. Monitor elderly or respiratory-compromised patients for excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Loratadine and Pregabalin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Pregabalin
Frequently asked questions
Can I take Loratadine with Pregabalin?
MediHelp rates the interaction as minor. Loratadine and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pregabalin causes somnolence and dizziness and carries a warning for respiratory depression with other CNS depressants. Loratadine is minimally sedating, so additive effects are likely small but may matter in vulnerable patients.
How serious is the interaction between Loratadine and Pregabalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel about drowsiness and driving. Monitor elderly or respiratory-compromised patients for excess sedation.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
