Drug interactions
Loratadine + Stiripentol
Severity: Minor
Loratadine and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein and several CYP enzymes, which may raise loratadine exposure. Loratadine has a wide safety margin so any clinical effect is expected to be small.
What this interaction means in plain words
Loratadine and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein and CYP-mediated metabolism by stiripentol increases loratadine levels.
What to do
Monitor for drowsiness or headache and reduce the loratadine dose if they occur. A less affected antihistamine can be used if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Loratadine with Stiripentol?
MediHelp rates the interaction as minor. Loratadine and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-glycoprotein and several CYP enzymes, which may raise loratadine exposure. Loratadine has a wide safety margin so any clinical effect is expected to be small.
How serious is the interaction between Loratadine and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness or headache and reduce the loratadine dose if they occur. A less affected antihistamine can be used if needed.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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