Drug interactions
Losartan + Nitisinone
Severity: Minor
Losartan and Nitisinone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, the main enzyme converting losartan to its more potent active metabolite. This may raise losartan and lower E-3174 exposure, with an unpredictable effect on blood pressure control.
What this interaction means in plain words
Losartan and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Nitisinone belongs to Miscellaneous.
Why it happens
Inhibition of CYP2C9 by nitisinone reducing losartan biotransformation.
What to do
Monitor blood pressure after starting nitisinone and adjust the losartan dose to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Losartan with Nitisinone?
MediHelp rates the interaction as minor. Losartan and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitisinone inhibits CYP2C9, the main enzyme converting losartan to its more potent active metabolite. This may raise losartan and lower E-3174 exposure, with an unpredictable effect on blood pressure control.
How serious is the interaction between Losartan and Nitisinone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting nitisinone and adjust the losartan dose to response.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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