Drug interactions
Lurasidone + Metoclopramide
Severity: Major
Lurasidone and Metoclopramide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block dopamine D2 receptors, so combining them increases the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Metoclopramide labeling advises avoiding use with antipsychotics.
What this interaction means in plain words
Lurasidone and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurasidone belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central dopamine D2 receptor antagonism.
What to do
Avoid metoclopramide in patients taking lurasidone and use an alternative antiemetic or prokinetic with less dopamine antagonism, such as domperidone-free options like ondansetron where appropriate. If unavoidable, monitor for movement disorders, rigidity and fever.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoclopramide
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Metoclopramide?
MediHelp rates the interaction as major. Lurasidone and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block dopamine D2 receptors, so combining them increases the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Metoclopramide labeling advises avoiding use with antipsychotics.
How serious is the interaction between Lurasidone and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metoclopramide in patients taking lurasidone and use an alternative antiemetic or prokinetic with less dopamine antagonism, such as domperidone-free options like ondansetron where appropriate. If unavoidable, monitor for movement disorders, rigidity and fever.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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