Drug interactions
Lurasidone + Prochlorperazine
Severity: Moderate
Lurasidone and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block dopamine receptors and cause sedation, so the combination raises the risk of drowsiness, extrapyramidal symptoms, and orthostatic hypotension. QT effects may also add up, though lurasidone has a low QT liability.
What this interaction means in plain words
Lurasidone and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive dopamine D2 antagonism and CNS depressant effects.
What to do
Monitor for sedation, movement disorders and hypotension. Prefer a non-dopamine-antagonist antiemetic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Prochlorperazine?
MediHelp rates the interaction as moderate. Lurasidone and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block dopamine receptors and cause sedation, so the combination raises the risk of drowsiness, extrapyramidal symptoms, and orthostatic hypotension. QT effects may also add up, though lurasidone has a low QT liability.
How serious is the interaction between Lurasidone and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, movement disorders and hypotension. Prefer a non-dopamine-antagonist antiemetic when feasible.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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