Drug interactions
Lurasidone + Tucatinib
Severity: Major
Lurasidone and Tucatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can increase exposure to lurasidone, a sensitive CYP3A4 substrate. This may lead to more sedation, extrapyramidal effects and other dose-related adverse events.
What this interaction means in plain words
Lurasidone and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurasidone belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibition of CYP3A4 reduces lurasidone clearance.
What to do
Avoid if possible; otherwise reduce the lurasidone dose and monitor for adverse effects. Consider an alternative antipsychotic not dependent on CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Lurasidone with Tucatinib?
MediHelp rates the interaction as major. Lurasidone and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib inhibits CYP3A4 and can increase exposure to lurasidone, a sensitive CYP3A4 substrate. This may lead to more sedation, extrapyramidal effects and other dose-related adverse events.
How serious is the interaction between Lurasidone and Tucatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the lurasidone dose and monitor for adverse effects. Consider an alternative antipsychotic not dependent on CYP3A4.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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