Drug interactions
Lurasidone + Vilazodone
Severity: Moderate
Lurasidone and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and lurasidone adds dopamine blockade, so the combination may rarely cause serotonin syndrome or neuroleptic malignant syndrome. Additive sedation may also occur.
What this interaction means in plain words
Lurasidone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects with dopamine D2 antagonism, a pharmacodynamic interaction.
What to do
Monitor for mental status change, neuromuscular hyperactivity, fever and rigidity, particularly after dose changes. Stop the drugs and treat supportively if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Vilazodone?
MediHelp rates the interaction as moderate. Lurasidone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, and lurasidone adds dopamine blockade, so the combination may rarely cause serotonin syndrome or neuroleptic malignant syndrome. Additive sedation may also occur.
How serious is the interaction between Lurasidone and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, neuromuscular hyperactivity, fever and rigidity, particularly after dose changes. Stop the drugs and treat supportively if toxicity develops.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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