Drug interactions
Macimorelin + Posaconazole
Severity: Moderate
Macimorelin and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in the QT interval, and posaconazole also prolongs it. Used together they may increase the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Macimorelin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Avoid the test while posaconazole is on board, or allow an adequate washout beforehand if the clinical situation permits. Otherwise, consider ECG monitoring and make sure electrolytes are normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Posaconazole?
MediHelp rates the interaction as moderate. Macimorelin and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small increase in the QT interval, and posaconazole also prolongs it. Used together they may increase the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Macimorelin and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the test while posaconazole is on board, or allow an adequate washout beforehand if the clinical situation permits. Otherwise, consider ECG monitoring and make sure electrolytes are normal.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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