Drug interactions
Magnesium sulphate + Nitrofurantoin
Severity: Minor
Magnesium sulphate and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium trisilicate and some magnesium antacids have been shown to reduce oral nitrofurantoin absorption. Magnesium sulphate specifically is less well studied, so the effect is probably small and may lower urinary drug levels.
What this interaction means in plain words
Magnesium sulphate and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium sulphate belongs to Cardiovascular; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Adsorption or binding of nitrofurantoin by magnesium salts in the gut may reduce absorption.
What to do
Separate oral nitrofurantoin from oral magnesium products by about 2 hours and monitor clinical response in urinary infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Magnesium sulphate with Nitrofurantoin?
MediHelp rates the interaction as minor. Magnesium sulphate and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium trisilicate and some magnesium antacids have been shown to reduce oral nitrofurantoin absorption. Magnesium sulphate specifically is less well studied, so the effect is probably small and may lower urinary drug levels.
How serious is the interaction between Magnesium sulphate and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral nitrofurantoin from oral magnesium products by about 2 hours and monitor clinical response in urinary infection.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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