Drug interactions
Magnesium sulphate + Rilpivirine
Severity: Moderate
Magnesium sulphate and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium-containing antacids can raise gastric pH, which reduces absorption of rilpivirine and may lower its plasma levels. This can compromise virologic suppression and promote resistance.
What this interaction means in plain words
Magnesium sulphate and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium sulphate belongs to Cardiovascular; Rilpivirine belongs to Anti Virals.
Why it happens
Increased gastric pH reduces the dissolution and absorption of rilpivirine.
What to do
Give antacids at least 2 hours before or 4 hours after rilpivirine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Magnesium sulphate with Rilpivirine?
MediHelp rates the interaction as moderate. Magnesium sulphate and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium-containing antacids can raise gastric pH, which reduces absorption of rilpivirine and may lower its plasma levels. This can compromise virologic suppression and promote resistance.
How serious is the interaction between Magnesium sulphate and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give antacids at least 2 hours before or 4 hours after rilpivirine.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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