Drug interactions
Maprotiline + Rolapitant
Severity: Moderate
Maprotiline and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is metabolized by CYP2D6, and rolapitant inhibits this enzyme for weeks after a dose. Higher maprotiline concentrations may increase the risk of seizures, sedation, anticholinergic effects and arrhythmia.
What this interaction means in plain words
Maprotiline and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, decreasing the metabolism of maprotiline.
What to do
Monitor for signs of toxicity, including CNS effects and ECG changes. Lower the maprotiline dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Rolapitant?
MediHelp rates the interaction as moderate. Maprotiline and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is metabolized by CYP2D6, and rolapitant inhibits this enzyme for weeks after a dose. Higher maprotiline concentrations may increase the risk of seizures, sedation, anticholinergic effects and arrhythmia.
How serious is the interaction between Maprotiline and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of toxicity, including CNS effects and ECG changes. Lower the maprotiline dose if needed.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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