Drug interactions
Maraviroc + Ribociclib
Severity: Moderate
Maraviroc and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 and P-gp substrate, and CYP3A4 inhibitors raise its concentrations, risking postural hypotension and other adverse effects. Ribociclib may therefore increase maraviroc exposure.
What this interaction means in plain words
Maraviroc and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated maraviroc metabolism by ribociclib.
What to do
Monitor for postural hypotension and hepatic effects, and adjust the maraviroc dose according to its labeling for CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Ribociclib?
MediHelp rates the interaction as moderate. Maraviroc and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 and P-gp substrate, and CYP3A4 inhibitors raise its concentrations, risking postural hypotension and other adverse effects. Ribociclib may therefore increase maraviroc exposure.
How serious is the interaction between Maraviroc and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for postural hypotension and hepatic effects, and adjust the maraviroc dose according to its labeling for CYP3A4 inhibitors.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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