Drug interactions
Maraviroc + Tipranavir
Severity: Minor
Maraviroc and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir does not produce a clinically meaningful increase in maraviroc exposure, because inhibition and induction effects offset one another. Maraviroc does not usually require adjustment with this combination.
What this interaction means in plain words
Maraviroc and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maraviroc belongs to Anti Virals; Tipranavir belongs to Anti Virals.
Why it happens
Opposing CYP3A inhibition by ritonavir and induction by tipranavir yield a net neutral effect on maraviroc.
What to do
Use maraviroc 300 mg twice daily with tipranavir/ritonavir. Monitor virologic response and tolerability as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Maraviroc with Tipranavir?
MediHelp rates the interaction as minor. Maraviroc and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tipranavir given with ritonavir does not produce a clinically meaningful increase in maraviroc exposure, because inhibition and induction effects offset one another. Maraviroc does not usually require adjustment with this combination.
How serious is the interaction between Maraviroc and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use maraviroc 300 mg twice daily with tipranavir/ritonavir. Monitor virologic response and tolerability as usual.
What other medicines interact with Maraviroc?
MediHelp also lists interactions of Maraviroc with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Maraviroc page.
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