Drug interactions
Maraviroc + Voriconazole
Severity: Moderate
Maraviroc and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases maraviroc exposure because maraviroc is cleared largely by CYP3A4. Higher levels can increase adverse effects such as postural hypotension, hepatotoxicity and infections.
What this interaction means in plain words
Maraviroc and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of maraviroc.
What to do
Reduce maraviroc to 150 mg twice daily when given with a strong CYP3A inhibitor, unless a CYP3A inducer is also present, per labeling. Monitor for hypotension and liver toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Voriconazole?
MediHelp rates the interaction as moderate. Maraviroc and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole increases maraviroc exposure because maraviroc is cleared largely by CYP3A4. Higher levels can increase adverse effects such as postural hypotension, hepatotoxicity and infections.
How serious is the interaction between Maraviroc and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce maraviroc to 150 mg twice daily when given with a strong CYP3A inhibitor, unless a CYP3A inducer is also present, per labeling. Monitor for hypotension and liver toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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