Drug interactions
Medroxyprogesterone + Ribociclib
Severity: Minor
Medroxyprogesterone and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may increase medroxyprogesterone exposure, potentially increasing progestogenic adverse effects. The effect is probably modest.
What this interaction means in plain words
Medroxyprogesterone and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing medroxyprogesterone metabolism.
What to do
No routine change is needed. Monitor for progestogenic adverse effects such as fluid retention or mood change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Medroxyprogesterone
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Medroxyprogesterone with Ribociclib?
MediHelp rates the interaction as minor. Medroxyprogesterone and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib may increase medroxyprogesterone exposure, potentially increasing progestogenic adverse effects. The effect is probably modest.
How serious is the interaction between Medroxyprogesterone and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for progestogenic adverse effects such as fluid retention or mood change.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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