Drug interactions
Medroxyprogesterone + Tazemetostat
Severity: Moderate
Medroxyprogesterone and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may modestly lower medroxyprogesterone concentrations. Contraceptive effectiveness could be reduced.
What this interaction means in plain words
Medroxyprogesterone and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Medroxyprogesterone belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat increases progestin clearance.
What to do
Advise an additional non-hormonal contraceptive method during tazemetostat treatment and for a period after stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Tazemetostat
Frequently asked questions
Can I take Medroxyprogesterone with Tazemetostat?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may modestly lower medroxyprogesterone concentrations. Contraceptive effectiveness could be reduced.
How serious is the interaction between Medroxyprogesterone and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during tazemetostat treatment and for a period after stopping.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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