Drug interactions
Medroxyprogesterone + Tipranavir
Severity: Moderate
Medroxyprogesterone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir has complex effects on CYP3A4 and may alter progestin exposure, possibly increasing adverse effects or reducing contraceptive efficacy. Data for medroxyprogesterone are limited.
What this interaction means in plain words
Medroxyprogesterone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Medroxyprogesterone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Mixed CYP3A4 inhibition and induction by tipranavir/ritonavir alters progestin metabolism.
What to do
Counsel on additional non-hormonal contraception and monitor for bleeding changes or progestogenic adverse effects. Consider alternative contraception if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Medroxyprogesterone with Tipranavir?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted tipranavir has complex effects on CYP3A4 and may alter progestin exposure, possibly increasing adverse effects or reducing contraceptive efficacy. Data for medroxyprogesterone are limited.
How serious is the interaction between Medroxyprogesterone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additional non-hormonal contraception and monitor for bleeding changes or progestogenic adverse effects. Consider alternative contraception if feasible.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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