Drug interactions
Medroxyprogesterone + Voriconazole
Severity: Minor
Medroxyprogesterone and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise medroxyprogesterone concentrations, potentially increasing progestogen-related adverse effects. The clinical impact is usually modest.
What this interaction means in plain words
Medroxyprogesterone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated medroxyprogesterone metabolism.
What to do
No routine dose change is needed; monitor for progestogenic adverse effects such as bleeding changes, fluid retention or mood changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Voriconazole?
MediHelp rates the interaction as minor. Medroxyprogesterone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may raise medroxyprogesterone concentrations, potentially increasing progestogen-related adverse effects. The clinical impact is usually modest.
How serious is the interaction between Medroxyprogesterone and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for progestogenic adverse effects such as bleeding changes, fluid retention or mood changes.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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