Drug interactions
Mefloquine + Nintedanib
Severity: Moderate
Mefloquine and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine is a P-glycoprotein substrate and inhibitor, so it may increase nintedanib exposure. Higher levels could worsen gastrointestinal toxicity and liver enzyme elevations.
What this interaction means in plain words
Mefloquine and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Nintedanib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by mefloquine may increase nintedanib absorption.
What to do
Monitor for diarrhea, nausea and liver enzyme rises, and reduce or interrupt nintedanib if not tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Mefloquine with Nintedanib?
MediHelp rates the interaction as moderate. Mefloquine and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine is a P-glycoprotein substrate and inhibitor, so it may increase nintedanib exposure. Higher levels could worsen gastrointestinal toxicity and liver enzyme elevations.
How serious is the interaction between Mefloquine and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, nausea and liver enzyme rises, and reduce or interrupt nintedanib if not tolerated.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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