Drug interactions
Mefloquine + Talazoparib
Severity: Moderate
Mefloquine and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine inhibits P-glycoprotein and talazoparib is a P-gp substrate, so talazoparib exposure may increase. This could heighten myelosuppression such as anemia and thrombocytopenia.
What this interaction means in plain words
Mefloquine and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Talazoparib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by mefloquine reduces talazoparib efflux and clearance.
What to do
Monitor complete blood counts closely. Consider reducing talazoparib dose per labeling if toxicity develops, or choose an alternative antimalarial.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Mefloquine with Talazoparib?
MediHelp rates the interaction as moderate. Mefloquine and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine inhibits P-glycoprotein and talazoparib is a P-gp substrate, so talazoparib exposure may increase. This could heighten myelosuppression such as anemia and thrombocytopenia.
How serious is the interaction between Mefloquine and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely. Consider reducing talazoparib dose per labeling if toxicity develops, or choose an alternative antimalarial.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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