Drug interactions
Melatonin + Mirtazapine
Severity: Minor
Melatonin and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote sleepiness, so combined use may produce additive drowsiness and next-day sedation. The clinical effect is generally mild.
What this interaction means in plain words
Melatonin and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive sedative effects via H1 antagonism and melatonin receptor agonism.
What to do
Counsel about daytime drowsiness and driving. Reduce or stop melatonin if residual sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Mirtazapine?
MediHelp rates the interaction as minor. Melatonin and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents promote sleepiness, so combined use may produce additive drowsiness and next-day sedation. The clinical effect is generally mild.
How serious is the interaction between Melatonin and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about daytime drowsiness and driving. Reduce or stop melatonin if residual sedation occurs.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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