Drug interactions
Melatonin + Stiripentol
Severity: Minor
Melatonin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin is cleared mainly by CYP1A2, and stiripentol has been shown in vitro to inhibit several CYP enzymes including CYP1A2. Melatonin exposure could therefore increase, causing greater daytime drowsiness, though clinical data are limited.
What this interaction means in plain words
Melatonin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP1A2-mediated melatonin metabolism by stiripentol.
What to do
Start with a low melatonin dose and monitor for excess sedation. Adjust the dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Melatonin with Stiripentol?
MediHelp rates the interaction as minor. Melatonin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin is cleared mainly by CYP1A2, and stiripentol has been shown in vitro to inhibit several CYP enzymes including CYP1A2. Melatonin exposure could therefore increase, causing greater daytime drowsiness, though clinical data are limited.
How serious is the interaction between Melatonin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low melatonin dose and monitor for excess sedation. Adjust the dose according to response.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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