Drug interactions
Melatonin + Trimipramine
Severity: Minor
Melatonin and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is strongly sedating and melatonin promotes sleepiness, so combined use may increase drowsiness and next-day impairment. Melatonin is also reported to have modest effects on CYP1A2, which is of uncertain relevance here.
What this interaction means in plain words
Melatonin and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Trimipramine belongs to Central Nervous System.
Why it happens
Additive central nervous system sedation from histamine H1 blockade by trimipramine and melatonin receptor agonism.
What to do
Counsel the patient about additive drowsiness and advise against driving until the response is known. Reduce the melatonin dose if daytime sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Trimipramine?
MediHelp rates the interaction as minor. Melatonin and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimipramine is strongly sedating and melatonin promotes sleepiness, so combined use may increase drowsiness and next-day impairment. Melatonin is also reported to have modest effects on CYP1A2, which is of uncertain relevance here.
How serious is the interaction between Melatonin and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and advise against driving until the response is known. Reduce the melatonin dose if daytime sedation occurs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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