Drug interactions
Melatonin + Zileuton
Severity: Minor
Melatonin and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin is cleared mainly by CYP1A2, and inhibitors of this enzyme raise its concentrations. Zileuton is a weak inhibitor, so effects such as next-day drowsiness may be increased but are generally mild.
What this interaction means in plain words
Melatonin and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, reducing melatonin clearance.
What to do
No routine action is needed. Use a lower melatonin dose if daytime sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Melatonin and Zileuton, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Zileuton?
MediHelp rates the interaction as minor. Melatonin and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin is cleared mainly by CYP1A2, and inhibitors of this enzyme raise its concentrations. Zileuton is a weak inhibitor, so effects such as next-day drowsiness may be increased but are generally mild.
How serious is the interaction between Melatonin and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Use a lower melatonin dose if daytime sedation occurs.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
