Drug interactions
Meperidine + Perampanel
Severity: Moderate
Meperidine and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel can cause dizziness, somnolence and impaired coordination, and opioids such as meperidine add to these effects. Patients may experience increased sedation and psychomotor impairment.
What this interaction means in plain words
Meperidine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression through different pharmacodynamic pathways (AMPA antagonism and opioid agonism).
What to do
Monitor for excess sedation, dizziness and falls, and counsel patients against driving. Lower the dose of either drug if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Meperidine with Perampanel?
MediHelp rates the interaction as moderate. Meperidine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel can cause dizziness, somnolence and impaired coordination, and opioids such as meperidine add to these effects. Patients may experience increased sedation and psychomotor impairment.
How serious is the interaction between Meperidine and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dizziness and falls, and counsel patients against driving. Lower the dose of either drug if impairment develops.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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