Drug interactions
Methamphetamine + Mirtazapine
Severity: Moderate
Methamphetamine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine releases monoamines including serotonin, so combination with a serotonergic antidepressant could increase the risk of serotonin syndrome, and hypertension and tachycardia may also occur. Opposing effects on sedation make the net effect unpredictable.
What this interaction means in plain words
Methamphetamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Methamphetamine-driven monoamine release adds to mirtazapine's serotonergic and noradrenergic activity.
What to do
Monitor blood pressure, heart rate and signs of serotonin toxicity such as agitation, tremor and hyperthermia. Stop methamphetamine and treat if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Mirtazapine?
MediHelp rates the interaction as moderate. Methamphetamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine releases monoamines including serotonin, so combination with a serotonergic antidepressant could increase the risk of serotonin syndrome, and hypertension and tachycardia may also occur. Opposing effects on sedation make the net effect unpredictable.
How serious is the interaction between Methamphetamine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of serotonin toxicity such as agitation, tremor and hyperthermia. Stop methamphetamine and treat if serotonin syndrome develops.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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