Drug interactions
Methamphetamine + Modafinil
Severity: Moderate
Methamphetamine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote wakefulness, and modafinil has weak sympathomimetic and dopaminergic effects. Combined use may increase insomnia, anxiety, and blood pressure and heart rate, although serious reactions are uncommon.
What this interaction means in plain words
Methamphetamine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Additive CNS stimulant and dopaminergic pharmacodynamic effects.
What to do
Monitor blood pressure, heart rate, sleep and anxiety symptoms when used together. Reduce the dose of one agent if stimulant adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methamphetamine and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Methamphetamine with Modafinil?
MediHelp rates the interaction as moderate. Methamphetamine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote wakefulness, and modafinil has weak sympathomimetic and dopaminergic effects. Combined use may increase insomnia, anxiety, and blood pressure and heart rate, although serious reactions are uncommon.
How serious is the interaction between Methamphetamine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, sleep and anxiety symptoms when used together. Reduce the dose of one agent if stimulant adverse effects emerge.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
