Drug interactions
Methamphetamine + Oxycodone
Severity: Moderate
Methamphetamine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine's stimulant effects may partly mask opioid sedation, which can hide the early signs of opioid toxicity, and the drugs have opposing effects on alertness. Both can also affect cardiovascular parameters, and the combination has no well-defined benefit.
What this interaction means in plain words
Methamphetamine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic CNS effects; stimulant may mask opioid sedation without reducing respiratory depression.
What to do
Monitor respiratory rate and cardiovascular status rather than relying on alertness alone. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Oxycodone?
MediHelp rates the interaction as moderate. Methamphetamine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine's stimulant effects may partly mask opioid sedation, which can hide the early signs of opioid toxicity, and the drugs have opposing effects on alertness. Both can also affect cardiovascular parameters, and the combination has no well-defined benefit.
How serious is the interaction between Methamphetamine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and cardiovascular status rather than relying on alertness alone. Use the lowest effective doses.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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