Drug interactions
Methamphetamine + Ozanimod
Severity: Major
Methamphetamine and Ozanimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites weakly inhibit MAO-B in vitro, which raises concern about potentiation of indirect sympathomimetics. Combined use could cause a rise in blood pressure, tachycardia and, theoretically, hypertensive crisis or serotonin toxicity. Clinical data are limited.
What this interaction means in plain words
Methamphetamine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methamphetamine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by ozanimod metabolites enhances the norepinephrine-releasing and pressor effects of methamphetamine.
What to do
Avoid the combination where possible. If used together, monitor blood pressure and heart rate closely and stop at signs of hypertensive or serotonergic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Ozanimod?
MediHelp rates the interaction as major. Methamphetamine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolites weakly inhibit MAO-B in vitro, which raises concern about potentiation of indirect sympathomimetics. Combined use could cause a rise in blood pressure, tachycardia and, theoretically, hypertensive crisis or serotonin toxicity. Clinical data are limited.
How serious is the interaction between Methamphetamine and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor blood pressure and heart rate closely and stop at signs of hypertensive or serotonergic toxicity.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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