Drug interactions
Methamphetamine + Propylhexedrine
Severity: Moderate
Methamphetamine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is a sympathomimetic used as a nasal decongestant. With methamphetamine it can add to sympathetic stimulation, causing higher blood pressure, tachycardia and agitation, particularly if it is misused or taken in large amounts.
What this interaction means in plain words
Methamphetamine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Additive adrenergic effects through indirect norepinephrine release.
What to do
Avoid propylhexedrine inhalers in patients taking methamphetamine. Monitor blood pressure and heart rate if the combination occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Methamphetamine with Propylhexedrine?
MediHelp rates the interaction as moderate. Methamphetamine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is a sympathomimetic used as a nasal decongestant. With methamphetamine it can add to sympathetic stimulation, causing higher blood pressure, tachycardia and agitation, particularly if it is misused or taken in large amounts.
How serious is the interaction between Methamphetamine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propylhexedrine inhalers in patients taking methamphetamine. Monitor blood pressure and heart rate if the combination occurs.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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