Drug interactions
Methamphetamine + Ranolazine
Severity: Minor
Methamphetamine and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is partly metabolized by CYP2D6, and ranolazine's weak inhibition of this enzyme may modestly raise its levels. Cardiovascular stimulation, including tachycardia and hypertension, could be more pronounced.
What this interaction means in plain words
Methamphetamine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methamphetamine belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Weak CYP2D6 inhibition by ranolazine may reduce methamphetamine metabolism.
What to do
Monitor heart rate and blood pressure. Reduce the methamphetamine dose if stimulant effects become excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Ranolazine?
MediHelp rates the interaction as minor. Methamphetamine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methamphetamine is partly metabolized by CYP2D6, and ranolazine's weak inhibition of this enzyme may modestly raise its levels. Cardiovascular stimulation, including tachycardia and hypertension, could be more pronounced.
How serious is the interaction between Methamphetamine and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure. Reduce the methamphetamine dose if stimulant effects become excessive.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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